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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related macular degeneration (AMD)
ncRNA name ITGA5 shRNA
ncRNA Category shRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line human choroidal endothelial cells
Methods shRNA knockdown, tube formation assay, transwell assay, MTS cell proliferation assay, Western blot
Expression pattern associated
Functional description Integrin α5 knockdown by shRNA inhibits endothelial cell migration, tube formation, and proliferation.
PubMed ID 27089240
Year 2016
Title Joint Antiangiogenic Effect of ATN-161 and Anti-VEGF Antibody in a Rat Model of Early Wet Age-Related Macular Degeneration.
Drug-related ncRNA NA

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